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You will be updated with latest job alerts via emailWe are looking for a highly skilled postdoctoral researcher with strong expertise in cell biology to join our NIHfunded project which focuses on identifying and characterizing heterotypic amyloid interactions as modulators of selective cellular vulnerability. As the project progresses we are entering a crucial phase that involves detailed cellular assays to explore and validate the roles of these interactions. Your expertise will be key in driving this exciting research forward and exploring the implications of these interactions in cellular systems.
Amyloid aggregates manifest in specific brain regions while sparing others. Our project aims to unravel whether heterotypic interactions between aggregationprone regions of amyloidforming proteins and the background proteome dictate this selective vulnerability. This hypothesis will be tested using a genomewide computational screen followed by experimental validation in cellular models and subsequently in mice. A key aspect of this research will involve cell biological techniques to validate interactions and elucidate how these alter cellular functions and drive disease processes.
The SWITCH Laboratory is a leading research group focused on the cell biology and biophysics of protein aggregation in human disease. Our interdisciplinary team of over twentyfive researchers including experts in cell biology bioinformatics biophysics and chemistry provides a rich environment for cuttingedge research. We are equipped with stateoftheart facilities for cellular and molecular biology including advanced microscopy highcontent screening and other tools essential for cell biology research. You can read more about us on our website and be sure to check out our laboratory section to explore the fantastic infrastructure that SWITCH has to offer!
As a key member of our heterotypics team you will be at the forefront of this project integrating your expertise in cellular biology with protein aggregation research. Working closely with the PIs of the Switch Lab this role offers a mix of handson experimental work and data analysis with robust administrative support to ensure you can focus on driving scientific discovery.
Starting Date: as soon as possible
For more information contact Please complete the online application procedure and include a detailed CV including list of publications a motivation letter and the contact information of at least two referees.
Full Time